Operating a shipping and distribution network in the cannabis supply chain is a complex, multifaceted endeavor. The sector remains tangled in a web of regulatory, financial, and operational constraints, even as states push cannabis legalization forward.
Regulatory Fragmentation and Compliance Overload
Every U.S. state has its own regulatory framework governing labeling, packaging, tracking, security, and permitted routes. One provider noted that distributors must navigate a patchwork of intrastate distribution rules, depending on the company’s home state, from vertically-integrated systems to outright bans on third-party shipments. Operators frequently wrestle with labeling requirements—child-resistant tamper-evident packaging, THC/CBD content, impairment warnings, and opaque containers are standard. This proliferation of rules forces logistics providers to continually update compliance training, SOPs, and packaging protocols.
Transportation Constraints and Insurance Burden
Unlike conventional freight, cannabis shipments cannot rely on standard carriers like UPS, FedEx, or USPS, and are barred from DOT-regulated trucks. Specialized providers fill the gap but at a steep price: armored vehicles with GPS, secure lockboxes, climate control, and high insurance premiums. The cost of outfitting a compliant delivery fleet is substantial. To reduce overhead, some opt for smaller vans traveling more frequently rather than larger trucks, accepting higher per-unit costs.
Driver Shortages and DOT Rules
At a time when trucking faces a driver shortage, cannabis logistics adds another layer. Drivers testing positive for THC are automatically disqualified from interstate business under DOT rules. This narrowing of the driver pool—even for intrastate travel—exacerbates scheduling constraints and raises driver compensation costs.
Security Risks
Cannabis shipments carry high criminal-risk. Cargo theft has surged, prompting distributors to implement tracking, security escorts, and background checks—measures that inflate overhead. Theft isn’t hypothetical; it’s operational risk with real revenue losses and insurance coverage implications.
Preserving Product Integrity
Cannabis products—especially flower, edibles, and beverages—are vulnerable to environmental stress. Fluctuating temperatures and humidity can degrade potency, promote mold, or compromise edibles. Maintaining precise climate control throughout transit adds complexity and cost. Some operators invest in cold-chain packaging like “Pallet Parkas” to supplement—and sometimes substitute—refrigerated transport.
Technology & Fragmented Supply Chain
Many cannabis businesses rely on outdated methods—paper records, manual inventory, fax orders—limiting operational efficiency. State-mandated seed-to-sale tracking demands integration with platforms like Metrc, placing heavy IT burdens on startups. Fragmentation persists with growers, processors, and labs operating separately, requiring communication, batch tracking, and coordination in real time.
Financial Strain and Cash-Centric Operations
Cannabis businesses often operate in cash due to banking restrictions. This “cash-only” norm hinders smooth financial planning, payroll, and vendor payments. It also amplifies security risks and complicates audits.
Opinion & Industry Perspective
Building a cannabis logistics arm is ultimately a gamble—on compliance, security, cost control, and infrastructure. But as legalization spreads and federal rescheduling looms, savvy operators see greenfield opportunities. Investing in modern ERP and compliance software, forging partnerships with trusted carriers, and developing standardized climate-controlled protocols are key strategies to scale efficiently. Third-party logistics providers—able to amortize technology, equipment, and expertise over multiple clients—hold distinct advantages in helping fragmented operators meet demand while mitigating risk.
Scaling cannabis freight is akin to navigating a minefield—with high stakes and high rewards. Those who master compliance, security, technology, and finance stand to win in a rapidly maturing and increasingly competitive market.
Read More: Why Shipping Costs Could Sink More Cannabis Firms Than Bad Weed

